{ "_id": "6a1ed831b401979e7340efde", "Package": "AllelicSeries", "Title": "Allelic Series Test", "Version": "0.1.1.5", "Authors@R": "c(person(given = \"Zachary\",\nfamily = \"McCaw\",\nemail = \"zmccaw@alumni.harvard.edu\",\nrole = c(\"aut\", \"cre\"),\ncomment = c(ORCID = \"0000-0002-2006-9828\")),\nperson(given = \"Christoph\",\nfamily = \"Klein\",\nemail = \"cklein@insitro.com\",\nrole = \"ctb\",\ncomment = c(ORCID = \"0000-0002-1748-625X\")),\nperson(given = \"Thomas\",\nfamily = \"Soare\",\nemail = \"tsoare@insitro.com\",\nrole = \"ctb\",\ncomment = c(ORCID = \"0000-0002-4903-8646\")),\nperson(given = \"Jianhui\",\nfamily = \"Gao\",\nemail = \"jianhui.gao@mail.utoronto.ca\",\nrole = \"ctb\",\ncomment = c(ORCID = \"0000-0003-0915-1473\")),\nperson(given = \"insitro\", role = c(\"cph\"))\n)", "Description": "Implementation of gene-level rare variant association\ntests targeting allelic series: genes where increasingly\ndeleterious mutations have increasingly large phenotypic\neffects. The COding-variant Allelic Series Test (COAST)\noperates on the benign missense variants (BMVs), deleterious\nmissense variants (DMVs), and protein truncating variants\n(PTVs) within a gene. COAST uses a set of adjustable weights\nthat tailor the test towards rejecting the null hypothesis for\ngenes where the average magnitude of effect increases\nmonotonically from BMVs to DMVs to PTVs. See McCaw ZR,\nO’Dushlaine C, Somineni H, Bereket M, Klein C, Karaletsos T,\nCasale FP, Koller D, Soare TW. (2023) \"An allelic series rare\nvariant association test for candidate gene discovery\"\n.", "License": "BSD_3_clause + file LICENSE", "URL": "https://github.com/insitro/AllelicSeries", "Encoding": "UTF-8", "Roxygen": "list(markdown = TRUE)", "RoxygenNote": "7.3.2", "Config/testthat/edition": "3", "VignetteBuilder": "knitr", "Repository": "https://insitro.r-universe.dev", "Date/Publication": "2025-10-22 19:31:46 UTC", "RemoteUrl": "https://github.com/insitro/allelicseries", "RemoteRef": "HEAD", "RemoteSha": "f7c182fc2ef25d78476ab97022db1160c7631e8c", "NeedsCompilation": "yes", "Packaged": { "Date": "2026-05-20 09:48:18 UTC", "User": "root" }, "Author": "Zachary McCaw [aut, cre] (ORCID:\n),\nChristoph Klein [ctb] (ORCID: ),\nThomas Soare [ctb] (ORCID: ),\nJianhui Gao [ctb] (ORCID: ),\ninsitro [cph]", "Maintainer": "Zachary McCaw ", "MD5sum": "35fada717db10bb00c9fe5a68970d108", "_user": "insitro", "_type": "src", "_file": "AllelicSeries_0.1.1.5.tar.gz", "_fileid": 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